ADAM10 anticorps

N° du produit ABIN7669976

Cet anticorps anti-ADAM10 est un anticorps Souris Monoclonal détectant ADAM10 dans FACS. Adapté pour Humain.

Aperçu rapide pour ADAM10 anticorps (ABIN7669976)

Antigène: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ADAM10 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: 11G2

Détail du produit anti-ADAM10 anticorps

Fonction: Purified Anti-Human ADAM10 Antibody[11G2]

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: ≥ 1 mg/mL

Buffer: Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: avoid freeze / thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur ADAM10

Antigène: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Autre désignation: ADAM10

Sujet: CDw,ADAM,ADAM metallopeptidase domain,a disintegrin and metalloprotease domain,a disintegrin and metalloproteinase domain,disintegrin and metalloproteinase domain-containing protein,ADAM10,AD10,AD18,CD156c,CDw156,HsT18717,MADM,RAK,kuz,Kuzbanian,a disintegrin and metalloprotease domain 10,a disintegrin and metalloproteinase domain 10,ADAM metallopeptidase domain 10,CD156c antigen,disintegrin and metalloproteinase domain-containing protein 10,Kuzbanian protein homolog,Mammalian disintegrin-metalloprotease,ADAM metallopeptidase domain 10,CD156c,CDw156,HsT18717,kuz,MADM,AD 10,ADA10,ADAM 10,CD 156c,disintegrin and metalloproteinase domain containing protein 10,Drosophila,homolog of,HsT 18717,Mammalian disintegrin metalloprotease,ADAM10 (also known as Kuzbanian, mammalian disintegrin metalloprotease, myelin-associated metalloproteinase) is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain . Like other membrane-anchored ADAMs, ADAM10 consists of the following domains, pro with a cysteine switch and furin cleavage sequence, catalytic with the zinc-binding site and Met-turn expected for reprolysins, disintegrin-like, cysteine-rich, EGF-like, transmembrane, and cytoplasmic. ADAM10 is highly conserved, with 97 % amino acid identity between mouse, rat, bovine and human and 45 % identity between mouse and Drosophila. The active enzyme processes notch, notch ligand delta, and amyloid protein precursor at the alpha site, playing an important role in neurogenesis . It also processes the 26 kDa membrane-anchored pro-tumor necrosis factor-alpha (TNF-alpha ) to the 17 kDa mature TNF-alpha. It cleaves myelin basic protein and type IV collagen. ADAM10 is widely expressed in tissues and resides both on the cell surface and in the cell.

UniProt: O14672

Pathways: Signalisation Notch, EGFR Signaling Pathway